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Zyrzine General Information

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Zyrzine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.

Zyrzine does not prevent hives or prevent/treat a serious allergic reaction (such as anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Zyrzine in place of your epinephrine.

How to Use Zyrzine

If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking Zyrzine. If you have any questions, consult your pharmacist. If your doctor has prescribed Zyrzine, take it as directed, usually once daily.

If you are using the chewable tablets, chew each tablet well and swallow. If you are using the rapidly-dissolving tablet, allow the tablet to dissolve on the tongue and then swallow, with or without water. If you are using the liquid form of Zyrzine, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take Zyrzine more often than directed.

Tell your doctor if your allergy symptoms do not improve, if your hives do not improve after 3 days of treatment, or if your hives last more than 6 weeks. Get medical help right away if your condition worsens or if you think you have a serious medical problem (such as a very serious allergic reaction/anaphylaxis).

Zyrzine Possible Side Effects

Drowsiness, tiredness, and dry mouth may occur. Stomach pain may also occur, especially in children. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has prescribed Zyrzine, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Zyrzine do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty urinating, weakness.

A very serious allergic reaction to Zyrzine is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Zyrzine Precautions

Before taking Zyrzine, tell your doctor or pharmacist if you are allergic to it; or to hydroxyzine; or to levoZyrzine; or if you have any other allergies. Zyrzine may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using Zyrzine, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (such as due to an enlarged prostate), kidney disease, liver disease.

If you are using Zyrzine to treat hives, tell your doctor right away if you have any of these other symptoms because they may be signs of a more serious condition: hives that are an unusual color, hives that look bruised or blistered, hives that do not itch.

Zyrzine may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Liquid products may contain sugar. Caution is advised if you have diabetes. Ask your doctor or pharmacist about using Zyrzine safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, Zyrzine should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Zyrzine Possible Intercations

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, other antihistamines (such as diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

Zyrzine is very similar to hydroxyzine and levoZyrzine. Do not use these medications while using Zyrzine.

Zyrzine may interfere with certain laboratory tests (including allergy skin testing), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Zyrzine.

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